The p53 protein is a critical tumour suppressor that acts as a barrier to the development and progression of incipient cancer cells. p53 function is lost during the development of most, if not all, cancers through a number of mechanisms including mutation of the TP53 gene itself or changes in expression of key regulators of p53 such as MDM2 and MDM4. p53 is involved in a wide range of cellular activities, both homeostatic and stress-induced, and its activation has several context-dependent outcomes including the elimination of cancer cells by apoptosis or senescence. p53 and key components of the network are under wide consideration as highly topical targets for therapeutic intervention. The aims of this group are as follows: To nucleate a collegiate association of p53 researchers (academic, industrial and clinical) in the UK with a view to stimulating contact and interchange. To provide a forum for discussion and exchange of information and knowledge on matters related to the p53 protein/gene and key components of the p53 network. To provide an avenue to stimulate collaboration or the exchange of key reagents. To promote interaction between basic science, industry and clinical application. We also hope that this group will lead to formal p53-focused scientific meetings and events.