Tumour Microenvironment and 3D Model Workshop

6th Sept     Day 1      3D Cancer Modelling Workshop 

10.00    Coffee and Registration
    
1030    Introduction and Welcome

Modelling stromal contribution in tumours

1035    Giulia Biffi, (CRUK Cambridge Institute)
            Deconstructing Pancreatic Ductal Adenocarcinomas 
1105    Talk Selected from abstracts - Olivier Pardo

            Crosstalk with lung fibroblasts shapes the growth and therapeutic response of    

            mesothelioma cells
1120    Talk Selected from abstracts - Rhianna Blyth

            Development of a 3D in vitro Breast Cancer Organotypic Model of Obesity  

            Associated Adipose Inflammation
    
Innovative technologies for tumour modelling

1135    Alvaro Mata, (University of Nottingham)  

            Biomimetic materials for tumour tissue engineering
1155    Carlos Reyes, (City University of London

            What do we mean by "Computational and Mathematical Modelling of the      

            Tumour Microenvironment"?
1220    Amanda Wright – (University of Nottingham)
            OptoRheo: 3D light sheet imaging and micro-mechanical sensing of live 3D cell

            culture systems over long time courses.
1245    Lunch and poster viewing
    
 Modelling the Immune landscape in vitro

1415    Keynote - Calvin Kuo – (Standford University, School of Medicine, USA)

            Organoid Modeling of Tumor and Tissue Microenvironments

1440    Talk Selected from abstracts -Eline Janssen

            Co-evolution of macrophages and fibroblasts in an in vitro model of colorectal

            cancer

1455    Talk Selected from abstracts - Keqian Nan

            Development of an ex vivo Image-Based Artificial Intelligence platform for

            Kidney precision oncology

1510    Talk Selected from abstracts - Vithurran Thavarajah

             Keeping it together:  Spatial transpcriptomic validation of patient-derived

             whole prostate tumour explant culture against paitent-matched primary           

             speciments from the SCREEN cohort

1525    Flash poster presentations
    
1615    Tea break
    
Translation to the clinic

1645    Greg Wells,  (University of Sheffield) 

            Ex-vivo screening in solid cancers, can we measure drug action at single cell   

            resolution?

1710    Geoff Pilkington, (Chair of the Animal Free Research UK)

            Advancement of sophisticated, dynamic human models of the brain tumour        

            microenvironment for pre-clinical drug efficacy and delivery testing [NAMs]
 

1735    Open floor discussion and closing remarks
 

1800    Drinks/nibbles and poster viewing
 

7th Sept    Day 2    Tumour Microenvironment

Session 1

0900    Keynote:  Prof Gabriele Bergers (Dept of Oncology KU, Leuven Belgium)

 

Session 2:  Vascular/lymphatic – Tumour Interactions

 

0945    Prof Hellmut Augustin (Heidelberg University)
            Vascular Control of Tumour Progression and Metastasis

1015    Dr Jacqui Shields (King College London)
            Exploring the role of stroma as immune modulators in the extended Tumour   
            Microenvironment
1045    Refreshment Break
    

Session 3:  Immune-Tumour Interactions

1115    Dr Stuart Hughes (Pathios Therapuetics, Oxford)

            GPR65 is a key sensor of low pH in the tumour microenvironment (TME) that

            drives the immunosuppresive polarization and exclusion of multiple immune

            cell subsets.
1145    Prof Sara Zanivan (CRUK Beatson Institute)

            Harnessing CAF metabolism to create an anti-tumour stroma

1215    Talk selected from abstracts:  Marc Rabionet Diaz

             Development of in vitro and in vivo tools to investigate the effects of the                   

             microenvironment on antigen-specific T Cell activation.
1230    Talk selected from abstracts: Sophie de Carne

             RAS oncogenic activity is associated with immune priming and escape in lung 

             adenocarcinoma 
     
1245     Lunch and Posters

             Sponsored Workshop

Aayush Sharma, Thermo Fisher

Next-Generation Sequencing Solutions Enable Deeper Insights into the Tumor   

Microenvironment    

 

Session 4: Tumour-Host/Stromal Interactions

1400    Dr Claus Jorgensen (CRUK Manchester Institute)
            Tumour-host interactions in the pancreatic cancer microenvironment

1430    Prof Jim Norman (CRUK Beatson Institute)
            The circulating metabolome of genetically engineered mouse models of             

            Mammary cancer reveals critical events in sending of lung metastases

1500    Talk selected from abstracts: Constantinos Demetriou

             Decoding Pancreatic Cancer's Tumour Microenvirment through Large-Scale                      

             Integration of Single-Cell RNA-Seq Datasets
 

1515    Talk selected from abstracts: Fátima de la Jara Ortiz

             In vitro generation and chargacterization of distince subtypes of cancer-          

             associated fibroblasts
 

1530    Refreshment break

 

Session 5: Metastasis

1600     Prof Janine Erler (Biotech Research & Innovation Centre)
             Modelling metastasis in native ECM organ scaffolds
1630     Prof Samra Turajlic, (Francis Crick Institute)

             Tumour microenvironment conditions that support emergence of  

             metastatic competence

1700     Talk selected from abstracts:  Oscar Maiques Carlos

             Extracellular matrix organisation at the invasive front of tumours generates a

             mechanical transcriptional memory in cancer cells during tumour                 

             dissemination.
1715     Talk selected from abstracts:  Mia Nuckhir

             Investigting the role of the lung microenvironment in the regulation of breast

             cancer metastatic colonization
1730     Networking time

1830    Drinks Reception in the Chemistry Theatre followed by the Conference Dinner

 

8th Sept     Day 3    Tumour Microenvironment  

  

0900    Keynote 2: Prof Peter Friedl (MD Anderson Cancer Centre), sponsored by the                   

            EACR

            Visualizing and modelling CTL - tumour cell interaction and additive                     

            Cytotoxicity

 

Session 6: Imaging    
        

0945    Prof Greg Hannon (CRUK Cambridge Institute)

            Impacts of tumour heterogeneity on disease progression and therapy  

            response 
      
1015    Dr MariamEleni Oraiopoulou (CRUK Cambridge Institute)
            Identifying vasulogenic mimicry and the effect of anti-vascular therapy with
            photoacoustics
1030    Talk selected from abstracts:  Sarah Gosling

             Prostate calcification as a marker of cancer: A multi-level X-ray analysis  
1045    Refreshment break  

 

 

Session 7: Hypoxia
    

1115    Prof Sonia Rocha (University of Liverpool)  

            Hypoxia changes chromatin structure to allow for specific cellular responses 

1145    Prof Ester Hammond (Oxford University)    
 

 

 

1215    Talk selected from abstracts:  Apple Tay

            VHL restoration in clear cell renal cell carcinoma improves NK cell infiltration 

            and function   
1230    Talk selected from abstracts:  Maria José Besso

            Methylation/gene expression changes underlying the response to           

            radiotchemotherapy with Nimorazole in head and  neck carcinoma xenografts.

          
1245    Lunch and posters    
        
Session 8: Into the clinic and patient perspective    
        
1400    Dr Simon Lord, Oxford University
            Repurposing metformin as cancer therapeutic

1430    Prof John Anderson, University College London    
1500    Talk selected from abstracts 10:  Jiabao Zhou

             Novel methods of targeting IL-1 signalling for the treatment of breast cancer

            bone metastasis  

1515    Invited Patient perspective talk 1    
1540    Invited Patient perspective talk 2    
 

1600    Closing Remarks/Poster Prize and meeting end.