- Salary in the range of £31,604 - £41,929 (dependent upon qualifications and experience)
- Job Ref: MI/19/12
- Duration: Fixed term for 3 years
About the role:
They are seeking a Postdoctoral Scientist to join the Molecular Oncology Group lead by Prof Richard Marais, Senior Group leader of the Molecular Oncology Group and Director of the CRUK Manchester Institute (www.cruk.manchester.ac.uk/MolOnc). This is an excellent opportunity for a self-motivated, innovative, meticulous and organised candidate with excellent communication and interpersonal skills. The post-holder will develop a project within SPECIFICANCER, our recently announced CRUK Grand Challenge which aims to understand how oncogenes drive cancer in a tissue-specific manner (cruk.org/specificancer).
One of the most important observations from cancer genetics is that bona fide cancer drivers show a bewildering spectrum of tissue specificity, which is undoubtedly rooted in the biology of tissues and plays a role in the efficacy of treatment paradigms. In particular, our group will focus on deciphering the mechanistic basis of the selectivity of mutations in the RAS signaling pathway as drivers of melanoma or non-melanoma skin cancer. Together with the other SPECIFICANCER teams, we will develop detailed understanding of how the genes that drive cancer do so in a tissue-specific manner. Our discoveries will allow scientists and physicians to better interpret the role of tissue and cellular context in their assessment of disease and subsequent treatment decisions.
You should have a PhD in a biomedical sciences discipline along with relevant experience working in an academic research setting. Skills in biochemistry, molecular and cellular biology and use of mouse models are essential for this post. Experience in high throughput assays and analysis of NGS datasets would be desirable.
Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.
They are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.
How to apply?
To apply for this position please visit our website: http://www.cruk.manchester.ac.uk/Opportunities/Opportunities-Home
For any informal enquiries about this post, please contact Dr Valeria Pavet via email: Valeria.Pavet@cruk.manchester.ac.uk
The deadline for receipt of applications is 15 April 2019.
First round of interviews planned for end of April-beginning of May 2019.